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Andy McDonagh - MPhil in Computational Biology 2004-5

[picture of Andy McDonagh]

First degree:

BSc (hons.) Biochemistry and Pharmacology (University of Leeds, 1998)

Research :

I currently hold an MRC doctoral training award and conduct both computational and wet biology research. I am interested in the molecular mechanisms underpinning opportunistic fungal pathogen infections. This is currently restricted to Candida glabrata, a major cause of death in immunocompromised patients. Much of my work will also be conducted in the brewers' yeast Saccharomyces cerevisiae, because of their close evolutionary relationship and the vast computational and molecular resources available for the latter. My computational biology interests currently focus on the statistical properties of biological networks, and their evolution. In my experimental work, I aim to build large datasets of protein-protein interactions, phenotype-stressor relationships and gene expression using microarray technology. I hope to find differences in the networks of S.cerevisiae and C.glabrata that can account for virulence.

Current Supervisors : Dr Ken Haynes and Dr Michael Stumpf School : Department of Infectious Diseases and Centre for Bioinformatics, Imperial College London.